Vagelos Program In Life Sciences And Management – Dr. P. Roy Vagelos, M.D., C’50, B.S. in Chemistry from the University of Pennsylvania College of Arts and Sciences and an M.D. from Columbia University School of Medicine. His profession – the
Phenomenology—Embodies the philosophy of Penn’s Life Sciences and Leadership Program. After completing his internship and residency at Massachusetts General Hospital in Boston, he joined the National Institutes of Health in Bethesda, where he served as a senior surgeon and later as chief of the Division of Comparative Biochemistry from 1956 to 1966. Began basic research on lipid metabolism and discovered acyl carrier protein (ACP) as a key factor in this process. Dr. Vagelos later transitioned from medicine to academia and became chairman of the Department of Biological Chemistry at Washington University School of Medicine in St. Louis. Louis, MO, where he founded and became director of the university’s Department of Biological and Biomedical Sciences. In doing so, he created an unprecedented model for combining a medical school and an undergraduate biology department, which was quickly imitated by many other universities.
Vagelos Program In Life Sciences And Management
In 1975 Dr. Vagelos left academia to join Merck, where he distinguished himself as a scientist and visionary company leader, first as senior vice president for research and then as CEO in 1984. He is perhaps best known in this field for his role in two major cases. He was not the only lead scientist behind the development of Merck’s statin drugs Lovastatin and Zocor. They are cardiovascular protective and therapeutic agents that lower blood cholesterol levels by inhibiting HMG-CoA reductase, the enzyme that catalyzes the carbon fixation step in food. cholesterol biosynthesis, and was a key proponent of Merck’s decision to provide free ivermectin to people in Africa and Central America to treat river blindness, a widespread, chronic and debilitating disease spread by black flies. At the height of his leadership in the 1980s and early 1990s, until his retirement as CEO and chairman of the board in 1994, Merck was considered the world leader in the pharmaceutical industry. Dr. Vagelos is the author of more than 100 scientific articles and is an elected member of the National Academy of Sciences (he is also a member of the Institute of Medicine), the American Academy of Arts and Sciences, and the American Philosophical Society. . . For his seminal work at ACP and leading Merck, Dr. Vagelos received the 1967 American Chemical Society Award for Enzymatic Chemistry, the 1995 National Academy of Sciences Award for Community Service in Chemistry, and was inducted into the National Business Hall of Fame. . 1995. In 1998, the School of Arts and Sciences presented him with the Distinguished Alumnus Award in recognition of his lifetime achievement in the sciences and humanities, and in 1999 the Franklin Institute honored him with the Bower Award in Business Administration. In curing river blindness.
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Current philanthropic activities of Dr. Vagelos are rich and diverse and continue to span the academic spectrum from medicine to industry. He is chairman of the Columbia University Campaign for the Advancement of Physicians and Surgeons and on the board of Regeneron Pharmaceuticals; co-chair of the New Jersey Center for the Performing Arts; The Danforth Foundation, Inc. administrator; and PepsiCo, Inc., Prudential Insurance Company of America, American School of Classical Studies in Athens, Estee Lauder Companies, Inc. director; and a former director of McDonnell Douglas.
At Penn, Drs. Vagelos was a member of the Board of Trustees from 1988 to 1999, and served as Chair from 1995 to 1999, as well as Chair of the Executive and Nominating Trustee Committee and a member of the Undergraduate Financial Aid Committee and the Council on Excellence. After his retirement from the Board, he was named Trustee Emeritus. Philip A. Rea is Professor of Biological Sciences in the College of Arts and Sciences and Distinguished Director of the Rebecca and Aria Beldelegrun Program in Life Sciences and Management at the University of Pennsylvania. Together with Dr. In 2005, he founded the Mark V. Pauly Roy and Diane Vagelos Program in Life Sciences and Management, which he continues to co-direct. Dr. Riya received a Ph.D. in Plant Biochemistry from the Department of Plant Sciences and Magdalen College, University of Oxford, United Kingdom. Shortly before joining the Penn faculty, he was team leader in the Department of Biochemistry at Rothamsted Research (formerly the Crop Research Institute), one of the oldest agricultural research institutions.
Dr. Rea’s primary research is aimed at understanding a wide range of transport and related phenomena, with a particular focus on alternative energy sources and cellular detoxification processes. He and his team have made major contributions to the understanding of an extremely wide range of biological transport and related phenomena, studying vacuolar proton pumps, ATP-binding cassette (ABC) transporters in plants and yeast, and the enzymological basis of heavy metal detoxification.
Dr. A secondary set of studies at the interface between biosciences and their applications focuses on case studies that take the difficult transition from discovery in the laboratory to success in the marketplace and/or at the scale of human endeavors. Such case studies include Statins: From Fungi to Drugs, Ivermectin and River Blindness, Does Lean Fat Beat Obesity? and “Metformin: Out of the Backwaters and into Mainstream”—four major articles aimed primarily at an educated lay readership. The article on statins is motivated by the feeling that the article on statins will be of great interest to educated members of the general public, as it illustrates how our understanding of cardiovascular disease has been fundamentally restructured and given to us. A better understanding of how statins work, what they do (which wouldn’t have happened if these drugs weren’t introduced) and how an amazing discovery parallels the discovery of penicillin is one of the most important biomedical breakthroughs. . Since the twentieth century. The need for another article on ivermectin arose from the realization that despite the enormity of the problem of river blindness, few of us in this part of the world know it exists, and even fewer know the link between it and this disease. As most of us know, deworming pills are given to protect pets and livestock from heartworm and similar parasitic infections. The third major article is a current review of the role of brown and light brown fat (“lean fat”) in maintaining white fat, excess of which is associated with cardiovascular disease, type 2 diabetes, and metabolic syndrome. . Whether readers are overweight themselves or know others who are overweight, this article is of general interest because it covers a number of unprecedented findings made only in recent years and, if interpreted, provides a platform for readers to better understand the role of obesity. Classic brown fat. How brown fat was discovered in newborn and hibernating mammals, adult animals, and humans, what it is and what it does, the biochemical basis of thermogenesis, and recent progress in identifying new therapeutic agents that may eventually be used to combat obesity. The fourth topic on metformin is particularly interesting because it deals with a drug that has become important despite its checkered history. His story has many consequences and is full of delays, uncertainties and setbacks and random accidents. It is a folk remedy with well-established clinical benefits and its exact mechanism of action has not been defined. However, this does not mean that it is reserved for the chosen ones or that it is not a structurally complex compound, both of which are far from the case. Metformin is the current standard of care for type 2 diabetes, one of the most common chronic diseases in the world, and its structure is very simple compared to many other drugs. Similarly, one of the latest articles by Dr. Rea’s “How Glyphosate Was Created” looks at the most important herbicide of all time, based on the billions of kilograms used on agricultural land worldwide. But what could be more unlikely given the success of this herbicide, known as Roundup, than the accidental discovery of it as a modified amino acid no larger than glucose, with an unnecessarily refined structure for any of its replacements? targeting an enzyme that has devastating consequences in a key pathway, the shikimate pathway, which we do not have but is essential to plant function; Incidental findings that followed
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